Protein Details: Aquaporin Z
Protein ID
ICDB_Pro_1551
Protein Name
Aquaporin Z
Gene Name
aqpZ; BMEI0070
Organism
Brucella melitensis biotype 1 (strain ATCC 23456 / CCUG 17765 / NCTC 10094 / 16M)
Length
228 amino acids
AlphaFoldDB
AF-Q9L772-F1-model_v4.pdb
Function
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Sequence
MLNKLSAEFFGTFWLVFGGCGSAILAAAFPELGIGFLGVALAFGLTVLTMAYAVGGISGGHFNPAVSLGLTVAGRLPAKDLIPYWVAQVLGAIAAAAILYVIASGKDGFSAGGLASNGYGELSPGGYSMMAGLLIEIILTAFFIIIILGSTSSLAPAGFAPIAIGFGLTLIHLVSIPVTNTWVNPARSTGVALFADTAALSQLWLFWVAPLVGAVIGAIIWKGLLGRD
PDB Structures
Ligand Binding
Binding Site
SITE 20: "Involved in tetramerization or stability of the tetramer"; SITE 43: "Selectivity filter"; SITE 172: "Selectivity filter"; SITE 181: "Selectivity filter"; SITE 187: "Selectivity filter"
Disease
Location
DOI ID
10.1073/pnas.221575398
RefSeq
WP_004684491.1